Anti-HER2 [ML3-9 (C6ML3-9)]

Absolute Antibody

Anti-HER2 [ML3-9 (C6ML3-9)]

9

This antibody is specific for HER2.

This antibody is an affinity matured version of the parent scFv antibody C6.5 (Schier et al,1996;pmid: 8918938). The ML3-9 scFv binds to the ErbB2 ECD with a KD of 1.1 nM. Another clone derived from ML3-9 An radioimmunoassay was performed on human serum using this antibody. The ability to bind HER2/neu was assesed in this antibody using surface plasmon resonance. An anti ErbB2/ErbB3 bispecific antibody made from ML3-9 and A5 clones called the A5-linker-ML3.9 bs-scFv exhibits selective targeting of tumour cells in vitro and in vivo that co-express the two target antigens over tumour cells that express only one target antigen or normal cells that express low levels of both antigens. This study was done using flow cytometry (Robinson et al, 2008;pmid:18841159).

Flow Cytometry, Other Application, RadioImmunoAssay

Research Use Only

Monoclonal

ML3-9 (C6ML3-9)

ERBB2

erb-b2 receptor tyrosine kinase 2

CD340; c-erb B2/neu protein; HER2; HER-2; HER-2/neu; herstatin; human epidermal growth factor receptor 2; metastatic lymph node gene 19 protein; MLN 19; NEU; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; NGL; proto-oncogene c-ErbB-2; proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; VSCN2

Human

IgG1

Receptor tyrosine-protein kinase erbB-2

This full-length, reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203