Anti-Her2/neu [HerG1M], Camelid VHH, His-tagged,

Absolute Antibody

Anti-Her2/neu [HerG1M], Camelid VHH, His-tagged,

9

This antibody is specific for human Her2/neu.

The binding specificity of this humanized single-domain antibody (sdAb; VHH) was tested in an ELISA. This antibody was used to generate an anti-Her2/neu and anti-human Ig bi-specific construct together with Ab04651 [C3]. The bi-specific construct was tested in vitro on BT474 breast cancer cells using a CCK8 assay and demonstrated a significant inhibitory effect on the growth of the breast cancer cells (approximately 50 times more effective than Herceptin). The bi-specific construct also exhibited a significantly prolonged stability in vivo in mice compared to the sdAb version of the antibody (CN110964113B).

ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

HerG1M

ERBB2

erb-b2 receptor tyrosine kinase 2

CD340; c-erb B2/neu protein; HER2; HER-2; HER-2/neu; herstatin; human epidermal growth factor receptor 2; metastatic lymph node gene 19 protein; MLN 19; NEU; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; NGL; proto-oncogene c-ErbB-2; proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; VSCN2

Camel

Receptor tyrosine-protein kinase erbB-2

Human

-20°C,2°C to 8°C

12352203