Anti-HER3 [A5 ]

Absolute Antibody

Anti-HER3 [A5 ]

7

This antibody is specific for HER3.

A5 scFv binds to ErbB3 ECD with a KD of 1.6 x 10-7 M. The ability to bind HER3 was assesed in this antibody using surface plasmon resonance. An anti ErbB2/ErbB3 bispecific antibody made from ML3-9 and A5 clones called the A5-linker-ML3.9 bs-scFv exhibits selective targeting of tumour cells in vitro and in vivo that co-express the two target antigens over tumour cells that express only one target antigen or normal cells that express low levels of both antigens. This study was done using flow cytometry. (Robinson et al, 2008;pmid:18841159).

Flow Cytometry, Other Application

SPR; FC

Research Use Only

Monoclonal

A5

ERBB3

erb-b2 receptor tyrosine kinase 3

c-erbB3; c-erbB-3; ErbB-3; erbB3-S; FERLK; HER3; human epidermal growth factor receptor 3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3; proto-oncogene-like protein c-ErbB-3; receptor tyrosine-protein kinase erbB-3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; VSCN1

Human

IgG1

Receptor tyrosine-protein kinase erbB-3

This full-length, reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

The original antibody was created using phage display from large naïve human scFv libraries.

-20°C,2°C to 8°C

12352203