Anti-Histone H2A Rabbit pAb

PTM BIO

Anti-Histone H2A Rabbit pAb

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Anti-Histone H2A Rabbit pAb detects endogenous levels of total histone H2A protein. It does not cross-react with other histone or non-histone proteins.

Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P

Antibody

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

Histone H2A type 1-B/E

Histones are a family of basic proteins that form the core of the nucleosome – the fundamental structural unit of chromatin. In a single nucleosome, core histone proteins H2A, H2B, H3, and H4 form an octamer around which the DNA is tightly wrapped. Among these core histones, the H2A family shows the highest sequence divergence, especially in the C-terminal region, leading to variants including H2A.Z, H2A.X, MacroH2A, H2A.B etc. Histone H2A helps regulate chromatin structure and function through specialized variants and a wide variety of post-translational modifications (PTMs). These PTMs including acetylation, ubiquitination, methylation, Phosphorylatedrylation, and novel acylations directly affect the accessibility of chromatin to transcription factors and other epigenetic regulators, altering genome stability and gene transcription.

Stable for 12 months from date of receipt/reconstitution.

Human, Monkey, Mouse, Rat

Human, Mouse, Rat, Monkey

Protein A and immunogen affinity purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203