Anti-Histone H3.3 Antibody [ST50-08]

HUABIO

Anti-Histone H3.3 Antibody [ST50-08]

7

ImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,ChIP

Research Use Only

Monoclonal

ST50-08

1 mg/ml

Unconjugated

H3-3A

H3.3 histone A

BRYLIB1, H3.3A, H3F3, H3F3A, histone H3.3, H3 histone family member 3A, H3 histone, family 3A

Rabbit

IgG

Histone H3.3

Eukaryotic histones are basic and water soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the octamer; formed of two H2A-H2B dimers and two H3-H4 dimers, forming two nearly symmetrical halves by tertiary structure. Over 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene, that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, sumoylation, ubiquitination and ADP-ribosylation.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161