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Anti-Histone H3.3 (Mutated K36M) Rabbit pAb

PTM-1014
PTM BIO
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
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Overview

  • Supplier
    PTM BIO
  • Product Name
    Anti-Histone H3.3 (Mutated K36M) Rabbit pAb
  • Delivery Days Customer
    5
  • Antibody Specificity
    Anti-Histone H3.3 (Mutated K36M) Rabbit pAb detects endogenous levels of K36M mutants of histone H3.1, H3.2, and H3.3 proteins.
  • Applications
    Western Blot
  • Applications Supplier
    WB
  • Category Supplier
    Antibody
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP84243
  • Protein Name
    Histone H3.3
  • Scientific Description
    K36M mutant of histone H3.3 is an oncohistone identified in more than 90% of chondroblastoma, a rare type of benign tumor caused by cartilage-producing cells. The mutant inhibits at least two H3K36 methyltransferases MMSET/WHSC1 and SETD2, triggering a depletion of H3K36 methylation and an increase of H3K27 trimethylation. H3.3K36M mutant proteins further alters expression of various genes including BMP2 that regulate oncogenesis and chondrogenesis. Chondrocytes expressing H3.3K36M exhibit several cancer-associated cellular phenotypes, including increased ability to form colonies, resistance to staurosporine-induced apoptosis, and defects in differentiation.
  • Shelf life instruction
    Stable for 12 months from date of receipt/reconstitution.
  • Reactivity
    Human
  • Reactivity Supplier
    Human
  • Reactivity Supplier Note
    Protein A and immunogen affinity purified
  • Storage Instruction
    Store at -20°C. Avoid freeze/thaw cycles.
  • UNSPSC
    12352203