Anti-Histone H4 [1A9D7]

Absolute Antibody

Anti-Histone H4 [1A9D7]

7

The antibody specifically recognizes simultaneous acetylations at K5 and K8 of histone H4. Lysine acetylation of core histones is one of the major posttranslational modifications involved in the control of eukaryotic gene expression.

The specificity of the original format of the antibody for histone H4 proteins containing di-acetylation of K5acK8ac was confirmed by ELISA analysis. The antibody detected the histone H4 proteins containing at least the di-acetylation of K5acK8ac western blot analysis. The crystal structure of the complex of di-acetylated histone H4 and 1A9D7 Fab fragment was determined (Handoko et al., 2018; PMID: 30080437).

Western Blot, ELISA, Other Application

Crystallization; ELISA; WB

Research Use Only

Monoclonal

1A9D7

H4C9

H4 clustered histone 9

H4 histone family, member M; H4/m; H4-16; H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4FM; H4M; HIST1H4I; histone 1, H4i; Histone 4 family, member M; histone cluster 1 H4 family member i; histone cluster 1, H4i; histone family member; histone H4

Human

IgG1

Histone H4

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG format for improved compatibility with existing reagents assays and techniques.

Human

Human

The original antibody was generated by immunizing mice with Histone H4 protein with site-specific acetylations at K5 and K8.

-20°C,2°C to 8°C

12352203