Anti-HIV-1 gp120 [694-D]

Absolute Antibody

Anti-HIV-1 gp120 [694-D]

9

694-D recognizes a neutralizing epitope of the hypervariable V3 loop of HIV-1 gp120.

This antibody was demonstrated to be neutralizing against HIV (Buchbinder et al., 1992; pmid: 1466965). It can be used synergistically with other neutralizing HIV antibodies (such as 447-D). This clone inhibits the binding of gp120 to soluble recombinant CD4 (Buchbinder et al., 1992; pmid: 1466965). Consequently, this antibody is recommended for research on the develpment of successful treatment and prevention of HIV infection, as effective neutralizing antibodies are capable of depleting the viral load in patients exposed to the virus.

Functional Assay, ImmunoFluorescence, Western Blot, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

694-D

env

Envelope surface glycoprotein gp160, precursor

Envelope surface glycoprotein gp160, precursor; HIV1gp8

Rabbit

IgG

Envelope glycoprotein gp160

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203