Anti-HIV-1 GP120 [VRC03]

Absolute Antibody

Anti-HIV-1 GP120 [VRC03]

9

This antibody binds CD4 binding site of the HIV-1 GP120.

The binding profile of this antibody towards HIV-1 GP120 was studied using ELISA and surface plasmon resonance. The original VRC03 IgG1 antibody, successfully neutralizes over 50% of current circulating HIV-1 isolates. (Mascola et al., US8637036). This antibody was reported to bind the resurfaced stabilized core 3 (RSC3) of the mutated HIV-1 envelop glycoprotein that is also capable of binding CD4. The original IgG1 version of this antibody has a binding affinity of KD = 7.31 x 10-8 M. (PMID: 20616233). VRC03 was found to potently inhibit entry into CD4+ T cells of HIV isolated from the latent viral reservoir of infected individuals whose plasma viremia was well controlled by antiretroviral therapy (ART) (PMID: 25157148).

ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

VRC03

Human

IgG1

Envelope glycoprotein gp160

Virus

-20°C,2°C to 8°C

12352203