Anti-HIV-1 GP120 [VRC03]

Absolute Antibody

Anti-HIV-1 GP120 [VRC03]

9

This antibody binds CD4 binding site of the HIV-1 GP120.

The binding profile of this antibody towards HIV-1 GP120 was studied using ELISA and surface plasmon resonance. The original VRC03 IgG1 antibody, successfully neutralizes over 50% of current circulating HIV-1 isolates. (Mascola et al., US8637036). This antibody was reported to bind the resurfaced stabilized core 3 (RSC3) of the mutated HIV-1 envelop glycoprotein that is also capable of binding CD4. The original IgG1 version of this antibody has a binding affinity of KD = 7.31 x 10-8 M. (PMID: 20616233). VRC03 was found to potently inhibit entry into CD4+ T cells of HIV isolated from the latent viral reservoir of infected individuals whose plasma viremia was well controlled by antiretroviral therapy (ART) (PMID: 25157148).

ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

VRC03

Rabbit

IgG

Envelope glycoprotein gp160

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

Virus

-20°C,2°C to 8°C

12352203