Anti-HIV-1 surface protein gp120 [447-D], Human IgG3, lambda

Absolute Antibody

Anti-HIV-1 surface protein gp120 [447-D], Human IgG3, lambda

9

This antibody is specific for the GPXR sequence of the gp120 V3 loop of HIV-1.

The original version of this antibody (human IgG3) was characterized for its specificity and reactivity using ELISA. It reacted with the V3 of HIV strains MN, SF-2, HXB2, RF, WM52, NY5, SC, and CDC4 with an affinity (Kd) of 0.56 microM, 0.9 microM, and 24.0 microM for MN, SF-2, and HXB2, respectively, and it reacted with the rgp120 of strains SF-2, HXB2 with an affinity of 0.01 microM and 3.9 microM. In an in vitro neutralization of HIV infectivity assay, this antibody achieved a geometric mean of neutralization endpoint [microg/ml] of 1.29 for HIVIIIB, 0.37 for HIVMN, 0.15 for HIVAL-1, 0.04 for HIVSF-2, 0.62 for HIVDU6587-5, 1.35 for HIVWMJ-2, 0.78 for HIVDU7887-7, 0.62 for HIVRF, and 1.98 for HIVSF-162 (US5914109A).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

447-D

Human

IgG3

Envelope glycoprotein gp160

Virus

-20°C,2°C to 8°C

12352203