Anti-HIV capsid protein p24 [13B5]

Absolute Antibody

Anti-HIV capsid protein p24 [13B5]

7

p24 is the major capsid protein of HIV and plays an active structural role both as part of the Gag polyprotein and in its processed form during virus assembly, maturation and disassembly. The association and dissociation rates and affinity constant for the formation of the 13B5 Fab complex with RH24 (the recombinant HIV-1 capsid protein) have been determined by surface plasmon resonance measurements (with affinity of 29nM). (PMID:11080628) PLA particles with surface adsorbed antigens p24 and gp120 were studied as new vaccine carriers. Competition ELISA was performed to investigate the influence of PLA adsorption on integrity and accessibility at the epitope level. Nanoparticle-adsorbed protein p24 was recognized by the antibody, indicating that the antigenicity and the structural integrity of PLA-adsorbed antigens was extremely well conserved. (PMID: 16919350)

ELISA, Other Application

ELISA; SPR

Research Use Only

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

-20°C,2°C to 8°C

12352203