Anti-HLA-A2 [MBW1]

Absolute Antibody

Anti-HLA-A2 [MBW1]

9

This antibody specifically reacts with human HLA-A2 and does not cross react with A28, Aw68, or Aw69 antigens (PMID: 2160447). The reactivity of this antibody to human HLA-A2 was determined using ELISA. The reactivity of this antibody towards HLA-A2 was abolished by substitutions in the a1 domain, specifically the substitutions of alanine for glutamic acid at position 58 (E58A) and either a valine or arginine substitution for glycine at position 62 (G62V or G62R). The reactivity of this antibody to surface bound HLA-A*0201 was determined using complement-dependent cytotoxicity (CDC) assay (PMID: 9862700).

Functional Assay, ELISA

Research Use Only

Monoclonal

MBW1

HLA-A

major histocompatibility complex, class I, A

HLAA, HLA class I histocompatibility antigen, A alpha chain, HLA class I histocompatibility antigen, A-1 alpha chain, MHC class I antigen HLA-A heavy chain, leukocyte antigen class I-A

Mouse

IgG2b

HLA class I histocompatibility antigen, A alpha chain

This chimeric mouse antibody was made using the variable domain sequences of the original Human IgM format for improved compatibility with existing reagents assays and techniques.

Human

-20°C,2°C to 8°C

12352203