Anti-HLA allele DQB10601 [LG11]

Absolute Antibody

Anti-HLA allele DQB1*0601 [LG11]

7

This antibody recognises peptides corresponding to the tip of the MHC antigen-binding cavity (region 70 - 90) of HLA allele DQB1*0601 (RTRAELDTVCRHNYEVAFRGI). It cross-reacts with peptide DQB1*03/70-90, and the shorter peptide DQB1*06/70-79

This antibody blocks the myasthenia gravis (MG)-associated DQ beta 1 allele, and is able to inhibit the proliferation of T cells from MG patients (Ayyar & Atassi, 2017). A humanised scFv derived from this antibody, which has been confirmed in ELISA analysis to recognise the same epitope, is also able to block the proliferation of T cells from MG patients typed DQB1*0601 (Ayyar & Atassi, 2017).

ELISA, Neutralisation/Blocking

ELISA; blocking

Research Use Only

Monoclonal

LG11

Mouse

IgG1

Human

Human

This antibody was raised by immunising BALB/c mice with unconjugated free synthetic DQB1 peptides (region 70–90).

-20°C,2°C to 8°C

12352203