Anti-HMGB1 Rabbit mAb

PTM BIO

Anti-HMGB1 Rabbit mAb

5

Flow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P, FC, IP

Research Use Only

Monoclonal

JRMR-10664-19

Unconjugated

Rabbit

IgG

High mobility group protein B1

Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203