Anti-HMGCR Antibody [JF0981]
ET1702-41
ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetHMGCR
Overview
- SupplierHUABIO
- Product NameAnti-HMGCR Antibody [JF0981]
- Delivery Days Customer7
- ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- Applications SupplierWB,IP,IHC-P
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDJF0981
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID3156
- Target nameHMGCR
- Target description3-hydroxy-3-methylglutaryl-CoA reductase
- Target synonymsLDLCQ3, LGMDR28, MYPLG, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, 3-hydroxy-3-methylglutaryl CoA reductase (NADPH), HMG-CoA reductase, hydroxymethylglutaryl-CoA reductase
- HostRabbit
- IsotypeIgG
- Protein IDP04035
- Protein Name3-hydroxy-3-methylglutaryl-coenzyme A reductase
- Scientific DescriptionThe human enzyme hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) limits the rate of cholesterol synthesis, a necessary process for cellular growth, in liver tissue. Phosphorylation of HMGCR inactivates the enzyme, which occurs via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Inhibitors of HMGCR (statins) exert anti-inflammatory effects and decrease the frequency of cardiovascular events by lowering plasma cholesterol. Additionally, intermediate products along the pathway catalyzed by HMGCR, which modulate signal transducing proteins such as Ras, provide possible ties between HMGCR regulation and new chemotherapeutic methods.
- ReactivityHuman
- Reactivity SupplierHuman
- Reactivity Supplier NoteMouse,Rat
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC41116161