Anti-hNaa50p Antibody

HUABIO

Anti-hNaa50p Antibody

7

Flow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P,FC

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Naa50

N(alpha)-acetyltransferase 50, NatE catalytic subunit

2600005K24Rik, 2810441M03Rik, Mak3, Mak3p, Nat13, Nat5, San, N-alpha-acetyltransferase 50, Mak3 homolog, Mak3p homolog, N-acetyltransferase 13, N-acetyltransferase NAT13, N-epsilon-acetyltransferase 50, Nalpha acetyltransferase 50, natE catalytic subunit

Rabbit

IgG

N-alpha-acetyltransferase 50

N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine . Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position . Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins . Autoacetylates in vivo . The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo . Component of a N-alpha-acetyltransferase complex containing NAA10 and NAA15, but NAA50 does not influence the acetyltransferase activity of NAA10: this multiprotein complex probably constitutes the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides . Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10 .

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161