Anti-Homer1 Antibody [JE65-19]

HUABIO

Anti-Homer1 Antibody [JE65-19]

2

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

JE65-19

1 mg/ml

Unconjugated

Homer1

homer scaffolding protein 1

PSD-Zip45, SYN47, Ves-1, homer-1, vesl-1, homer protein homolog 1, VASP/Ena-related gene up-regulated during seizure and LTP 1, homer homolog 1, homer, neuronal immediate early gene, 1, immediate early gene protein Homer1A

Rabbit

IgG

Homer protein homolog 1

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.

-20°C,2°C to 8°C

41116161