Anti-HP1 alpha Antibody [B0-1]

HUABIO

Anti-HP1 alpha Antibody [B0-1]

7

ImmunoFluorescence, Western Blot

WB,IF-Cell

Research Use Only

Monoclonal

B0-1

2 mg/ml

Unconjugated

Cbx5

chromobox 5

2610029O15Rik, HP1, Hp1a, Hp1alpha, chromobox protein homolog 5, HP1 alpha, chromobox homolog 5, heterochromatin protein 1 alpha, heterochromatin protein 1 homolog alpha, mHP1(alpha)

Mouse

IgG1

Chromobox protein homolog 5

Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene. It is a highly conserved, non-histone protein part of the heterochromatin family. The protein itself is more commonly called (in humans) HP1alpha. Heterochromatin protein-1 (HP1) has an N-terminal domain that acts on methylated lysines residues leading to epigenetic repression. The C-terminal of this protein has a chromo shadow-domain (CSD) that is responsible for homodimerizing, as well as interacting with a variety of chromatin-associated, non-histone proteins. HP1alpha is a highly evolutionary conserved protein, existing in species such a Schizosaccharomyces pombe, a type of yeast, all the way to humans. The N-terminal chromodomain and C-terminal chromoshadow domain appear to be much more conserved (approximately 50-70% amino acid similarity) than the hinge region (approximately 25-30% similarity with the Drosophila HP1 homolog).

Human

Human

Mouse

-20°C,2°C to 8°C

41116161