Anti-HSP90 [Myc123 (Efungumab; Mycograb)], Rabbit IgG, kappa

Absolute Antibody

Anti-HSP90 [Myc123 (Efungumab; Mycograb)], Rabbit IgG, kappa

9

This antibody binds an epitope comprising amino acid sequence NKILKVIRKNIVKK of heat shock protein 90 of Candida albicans. Homologous epitope have been identified in a number of fungal species like Candida parapsilosis, Torulopsis glabrata, Candida tropic

This anti-fungal antibody has been used for the antibody based therapeutic treatment of systemic and invasive candidiasis (PMID: 11566001; 15040939). In an in vitro assays for efficacy assessment this antibody showed activity against a wide range of yeast species like Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata, and Candida parapsilosis. Murine kinetics showed that Mycograb at 2 mg/kg produced a maximum concentration of drug in serum of 4.7 ug/ml which produced significant improvement in murine candidiasis caused by each species. Complete resolution of infection was achieved for C.albicans, C. krusei, and C. glabrata only after combination with amphotericin B (PMID: 12821470). In a double-blind, randomized study comprising 139 patients it was reported that Mycograb plus lipid-associated amphotericin B produced significant clinical and culture-confirmed improvement in outcome for patients with invasive candidiasis (PMID: 16619152).

ELISA

Research Use Only

Monoclonal

Myc123 (Efungumab; Mycograb)

Rabbit

IgG

Fungus

-20°C,2°C to 8°C

12352203