Anti-Hu CD40 APC

EXBIO

Anti-Hu CD40 APC

7

Flow cytometry: The reagent is designed for analysis of human blood cells using 10 microl reagent / 100 microl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Flow Cytometry

Research Use Only

HB14

APC (Allophycocyanin)

IgG1

CD40 is a costimulatory molecule of the TNF receptor superfamily and is expressed on many cell types, such as B cells, monocytes/macrophages, dendritic cells, endothelial cells, fibroblasts or vascular smooth muscle cells. Interaction of CD40 and its ligand CD154 (CD40L) is required for the generation of antibody responses to T-dependent antigens as well as for the development of germinal centers and memory B cells. In monocytes/macrophages CD40 engagement induces production of pro-inflammatory cytokines and chemokines. CD40-CD154 interactions are also critical for development of CD4 T cell-dependent effector functions. CD40 links innate and adaptive immune responses to bacterial stimuli and serves as an important regulator affecting functions of other costimulatory molecules.

2°C to 8°C

12352203