Anti-Human TNF-beta Antibody [PS01-19]

HUABIO

Anti-Human TNF-beta Antibody [PS01-19]

2

ELISA

Research Use Only

Monoclonal

PS01-19

1 mg/ml

Unconjugated

LTA

lymphotoxin alpha

LT, TNFB, TNFSF1, TNLG1E, lymphotoxin-alpha, LT-alpha, TNF superfamily, member 1, TNF-beta, tumor necrosis factor beta, tumor necrosis factor ligand 1E, tumor necrosis factor ligand superfamily member 1

Rabbit

IgG

Lymphotoxin-alpha

Tumor necrosis factor-beta (TNF-beta) is a protein that in humans is encoded by the LTA gene. Belonging to the hematopoietic cell line, LT-alpha exhibits anti-proliferative activity and causes the cellular destruction of tumor cell lines. As a cytotoxic protein, LT-alpha performs a variety of important roles in immune regulation depending on the form that it is secreted as. Unlike other members of the TNF superfamily, LT-alpha is only found as a soluble homotrimer, when found at the cell surface it is found only as a heterotrimer with LTbeta. LT-alpha has a significant impact on the maintenance of the immune system including the development of secondary lymphoid organs. Absence of LT-alpha leads to the disruption of gastrointestinal development, prevents Peyers patch development, and results in a disorganized spleen. As a signaling molecule, LT-alpha is involved in the regulation of cell survival, proliferation, differentiation, and apoptosis. LT-alpha plays an important role in innate immune regulation and its presence has been shown to prevent tumor growth and destroy cancerous cell lines. In contrast, unregulated expression of LT-alpha can result in a constantly active signaling pathway, thus leading to uncontrolled cellular growth and creation of tumors. Hence depending on the context, LT-alpha may function to prevent growth of cancer cells or facilitate the development of tumors. Furthermore, LT-alpha effects depend on the type of organ it acts upon, type of cancer cells, cellular environment, gender, and time of effect during an immune response.

-20°C,2°C to 8°C

41116161