Anti-ICOS ligand [Clone 223]

Absolute Antibody

Anti-ICOS ligand [Clone 223]

9

The scFv version of this antibody binds B7RP-1-Fc with a Kd= 14nM. The binding specificity of this antibody was confirmed using ELISA. This scFv version of this antibody was shown to bind B7RP-1-Fc in an ELISA. This antibody recognized B7RP-1 molecules expressed on B cells, as assessed by flow cytometry. This antibody is capable of inhibiting interaction between ICOS-Fc and B7RP-1-Fc. This antibody also exhibited inhibitory activity in a proliferation assay of T cells stimulated with anti-CD3 mAb and B7RP-1-Fc (PMID:20065650).

Flow Cytometry, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

Clone 223

ICOSLG

inducible T cell costimulator ligand

B7-H2, B7H2, B7RP-1, B7RP1, B7h, CD275, GL50, ICOS-L, ICOSL, IMD119, LICOS, ICOS ligand, B7 homolog 2, B7 homologue 2, B7-like protein Gl50, B7-related protein 1, transmembrane protein B7-H2 ICOS ligand

Human

IgG1

ICOS ligand

This full-length, reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203