anti-IgE antibody [4G7]

Arigo Biolaboratories

anti-IgE antibody [4G7]

23

Flow Cytometry, ELISA

Research Use Only

Monoclonal

4G7

1 mg/ml

Unconjugated

>95%

IGHE

immunoglobulin heavy constant epsilon

constant region of heavy chain of IgE; IgE; immunoglobulin epsilon

Mouse

IgG

Immunoglobulin E (IgE) is a 180 kDa soluble protein serving as an antigen-specific unit of mast cell effector mechanisms. IgE has the lowest serum concentration of all immunoglobulins (approximately 0.5 mg/l) in healthy individuals, but upon allergen challenge its concentration in blood increases dramatically. Although biological survival of free IgE is very short (T1/2 = 2 days), it is stabilized after binding to its high affinity receptor. Unlike IgM- IgG- and IgA-committed B cells, IgE-switched B cells do not undergo clonal expansion.

Human

-20°C

12352203