Anti-IgE [huMaE11 (Omalizumab)]

Absolute Antibody

Anti-IgE [huMaE11 (Omalizumab)]

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This antibody binds to circulating human IgE antibody, but not to cell-bound IgE. It binds in proximity of the binding site of the high-affinity IgE receptor Fc epsilon RI.

This antibody is the humanized version of original mouse antibody MAE11. This antibody binds to circulating IgE, thereby inhibiting IgE binding to mast-cells. It does not bind to cell-bound IgE and does not provoke histamine release from mast-cells sensitised by IgE. As a human IgG1, marketed as Xolair™, it is used therapeutically to treat asthma and allergies.

ELISA, Neutralisation/Blocking, Other Application

block; ELISA; crystallization

Research Use Only

Monoclonal

huMaE11 (Omalizumab)

Human

IgG1

Immunoglobulin heavy constant epsilon

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

Human

Human

Human IgE protein.

-20°C,2°C to 8°C

12352203