Anti-IgE [huMaE11 (Omalizumab)]

Absolute Antibody

Anti-IgE [huMaE11 (Omalizumab)]

9

This antibody binds to circulating human IgE antibody, but not to cell-bound IgE. It binds in proximity of the binding site of the high-affinity IgE receptor Fc epsilon RI.

This antibody is the humanized version of original mouse antibody MAE11. This antibody binds to circulating IgE, thereby inhibiting IgE binding to mast-cells. It does not bind to cell-bound IgE and does not provoke histamine release from mast-cells sensitised by IgE. As a human IgG1, marketed as Xolair™, it is used therapeutically to treat asthma and allergies.

ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

huMaE11 (Omalizumab)

Mouse

IgG2a

Immunoglobulin heavy constant epsilon

This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203