Anti-IgE [mAbA9]

Absolute Antibody

Anti-IgE [mAbA9]

9

This antibody binds to the extracellular membrane-proximal domain (EMPD) of mouse membrane-bound IgE with high specificity and affinity, as confirmed in ELISA analysis and FC analysis (Feichtner et al, 2008). In mice immunised with recombinant Bet v1a, the major birch pollen allergen, subsequent passive immunization with this antibody leads to a block of newly synthesized specific IgEs, and reduces serum Bet v1a-specific IgE titers (Feichtner et al, 2008). In vitro, this antibody induces receptor-mediated apoptosis in B cells expressing membrane-bound IgE (Feichtner et al, 2008).

Flow Cytometry, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

mAbA9

Rabbit

IgG

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Mouse

-20°C,2°C to 8°C

41116161