Anti-IKK alpha + IKK beta Antibody [SN63-02]

HUABIO

Anti-IKK alpha + IKK beta Antibody [SN63-02]

7

ImmunoFluorescence, ImmunoPrecipitation, Western Blot

WB,IF-Cell,IF-Tissue,IP

Research Use Only

Monoclonal

SN63-02

1 mg/ml

Unconjugated

CHUK

component of inhibitor of nuclear factor kappa B kinase complex

BPS2, IKBKA, IKK-1, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16, inhibitor of nuclear factor kappa-B kinase subunit alpha, I-kappa-B kinase 1, I-kappa-B kinase-alpha, IKK-a kinase, IkB kinase alpha subunit, Nuclear factor NFkappaB inhibitor kinase alpha, conserved helix-loop-helix ubiquitous kinase, transcription factor 16

Rabbit

IgG

Inhibitor of nuclear factor kappa-B kinase subunit beta

IKK-alpha is part of the IkappaB kinase complex that plays an important role in regulating the NF-kappaB transcription factor. IKK-beta is an enzyme that serves as a protein subunit of IkappaB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. IKKs activity causes activation of a transcription factor known as Nuclear Transcription factor kappa-B or NF-kappaB. Activated IKK-beta phosphorylates a protein called the inhibitor of NF-kappaB, IkappaB (IkappaBalpha), which binds NF-kappaB to inhibit its function. IKK-alpha and IKK-beta phosphorylate the IkappaB proteins, marking them for degradation via ubiquitination and allowing NF-kappaB transcription factors to go into the nucleus. Once activated, NF-kappaB transcription factors regulate genes that are implicated in many important cellular processes, including immune response, inflammation, cell death, and cell proliferation.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161