Anti-IL-10R [1B1.3a]

Absolute Antibody

Anti-IL-10R [1B1.3a]

7

1B1.3a has been widely applied in flow cytometric analyses where the detection of IL-10R was needed. Furthermore, this antibody was also successfully utilised as a blocking agent; one group used it to demonstrate that IL-10 mediates suppressive activity, by targeting its receptor IL-10R with this antibody (Wang et al., 2004). Castro et al. (2000) demonstrated that 1B1.3a is able to make a soluble peptide or protein antigen immunogenic for subsequent Th1 recall responses in a situation when there is an additional signal, such as LPS, activating the immune system. Consequently, this antibody is a hugely promising agent in the potential development of vaccines for immunotherapy. Similarly, Vicari and colleagues (2002) showed that this antibody has an enormous potential as a therapeutic anti-tumour agent when combined with the administration of CpG to stimulate the immune system.

Flow Cytometry, Neutralisation/Blocking

FC; blocking

Research Use Only

Monoclonal

1B1.3a

Il10ra

interleukin 10 receptor, alpha

CDw210, CDw210a, IL-10R1, IL-10RA, Il10r, mIL-10R, interleukin-10 receptor subunit alpha, IL-10 receptor subunit alpha, IL-10R subunit 1, IL-10R subunit alpha, interleukin-10 receptor subunit 1

Mouse

IgG2a

Interleukin-10 receptor subunit alpha

This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Mouse

This antibody was raised by immunising rats with the purified recombinant extracellular region of mouse Interleukin 10 Receptor.

-20°C,2°C to 8°C

12352203