Anti-IL-10R [1B1.3a]

Absolute Antibody

Anti-IL-10R [1B1.3a]

9

This antibody recognises mouse IL-10R which is a cell surface glycoprotein and a receprot for anti-inflammatory IL-10. The epitope recognised by this antibody has been localised to the ligand binding domain within the extracellular region of mouse IL-10R.

1B1.3a has been widely applied in flow cytometric analyses where the detection of IL-10R was needed. Furthermore, this antibody was also successfully utilised as a blocking agent; one group used it to demonstrate that IL-10 mediates suppressive activity, by targeting its receptor IL-10R with this antibody (Wang et al., 2004). Castro et al. (2000) demonstrated that 1B1.3a is able to make a soluble peptide or protein antigen immunogenic for subsequent Th1 recall responses in a situation when there is an additional signal, such as LPS, activating the immune system. Consequently, this antibody is a hugely promising agent in the potential development of vaccines for immunotherapy. Similarly, Vicari and colleagues (2002) showed that this antibody has an enormous potential as a therapeutic anti-tumour agent when combined with the administration of CpG to stimulate the immune system.

Flow Cytometry, Neutralisation/Blocking

Research Use Only

Monoclonal

1B1.3a

Il10ra

interleukin 10 receptor, alpha

AW553859; CDw210; CDw210a; Il; IL-10 receptor subunit alpha; Il10r; IL-10R subunit 1; IL-10R subunit alpha; IL-10R1; IL-10RA; interleukin-10 receptor subunit 1; interleukin-10 receptor subunit alpha; mIL-; mIL-10R

Rabbit

IgG

Interleukin-10 receptor subunit alpha

This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Mouse

-20°C,2°C to 8°C

12352203