Anti-IL-13 [M1295]

Absolute Antibody

Anti-IL-13 [M1295]

9

This antibody binds human interleukin-13 at the surface of helices A and D close to N- and C-termini of the IL-13 polypeptide chain. IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, eosi

This antibody can bind human IL13 in an ELISA. The affinity of original IgG1 antibody for wild type human IL-13 was determined by BIAcore to be 5.7 +/- 1.3 pM (PMID: 20226193). Preclinical studies confirm the functional effects of M1295-mediated neutralization of human IL-13 in human cell based in vitro assays using mechanistically relevant endpoints associated with the pathogenesis of asthma, atopic dermatitis, and eosinophil-mediated disease (US8399630).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

M1295

IL13

interleukin 13

IL-13; interleukin-13; P600

Mouse

IgG2b

Interleukin-13

This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

Human

-20°C,2°C to 8°C

12352203