Anti-IL-18 Mouse mAb

PTM BIO

Anti-IL-18 Mouse mAb

5

Western Blot

WB

Research Use Only

Monoclonal

JMMR-2351

Unconjugated

Mouse

IgG

Interleukin-18

Interleukin-18 (IL-18), also known as interferon-gamma inducing factor (IGIF), is part of the IL-superfamily of cytokines. This proinflammatory cytokine is synthesized as an inactive precursor which requires cleavage by Caspase-1 to become an active, mature molecule, which is secreted by monocytes and macrophages. It induces IFNgamma production in T-helper-1 (Th1) cells and natural killer (NK) cells, and can regulate innate immunity via both Th1 and Th2 responses. Elevated IL-18 levels are associated with autoimmune disease, but may be balanced by binding to IL-18 binding protein (IL-18BP), which along with IL-18 neutralizing antibodies, are being examined in clinical trials.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203