Anti-IL-1B [1]

Absolute Antibody

Anti-IL-1B [1]

7

The antibody is specific for chicken IL-1beta, a pleiotropic molecule with a wide spectrum of activities including metabolic, physiologic, hematologic, and immunologic effects. The antibody did not react with chicken IL-18.

The specificity of the original format of this antibody was confirmed by ELISA analysis (Lee et al, 2014; pmid: 25037821). The antibody detected chIL-1beta protein by Western blot analysis. The antibody was used as a capture antibody for measuring serum IL-1B levels in chicken by capture ELISA analysis. The original format of the antibody was used to localize IL-1beta-secreting cells in chicken immune tissues. The antibody neutralized the bioactivity of chIL-1B-induced cell proliferation and NO production by primary thymocytes (Lee et al, 2014; pmid: 25037821).

Western Blot, ELISA, ImmunoHistoChemistry, Neutralisation/Blocking

ELISA; WB; neutralizing; IH

Research Use Only

Monoclonal

1

IL1B

interleukin 1, beta

IL-1 beta; IL1beta; IL-1BETA; interleukin-1 beta

Rabbit

IgG

Interleukin-1

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Chicken

Chicken

The original antibody was raised immunising BALB/C mice with recombinant chicken IL-1B protein.

-20°C,2°C to 8°C

12352203