anti-IL-36beta (human), mAb (Jacky-1)

AdipoGen Life Sciences

anti-IL-36beta (human), mAb (Jacky-1)

10

Recognizes human IL-36beta. Does not cross-react with mouse IL-36beta and IL-36gamma.

Western Blot, ELISA

Research Use Only

Monoclonal

Jacky-1

1 mg/ml

>95%

Mouse

IgG1

IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. - Monoclonal Antibody. Recognizes human IL-36beta. Does not cross-react with mouse IL-36beta and IL-36gamma. Isotype: Mouse IgG1kappa. Clone: Jacky-1. Applications: ELISA, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.

Human

2°C to 8°C,-20°C

12352203