Mouse and human IL-38 is detected using anti-IL-38, mAb (Nhat-1) (AG-20B-0070).Method: Recombinant mouse IL-38 (AG-40B-0101) (lane 1), cell extracts from HEK 293 cells mock-transfected (lane 2) or transfected with human IL-38 (lane 3) were se
anti-IL-38, mAb (Nhat-1)
AG-20B-0070
Overview
- SupplierAdipoGen Life Sciences
- Product Nameanti-IL-38, mAb (Nhat-1)
- Delivery Days Customer10
- Antibody SpecificityRecognizes human and mouse IL-38.
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDNhat-1
- Concentration1 mg/ml
- Estimated Purity>95%
- FormulationLiquid
- HostMouse
- IsotypeIgG2b
- Scientific DescriptionIL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 as a IL-1 family receptor antagonist. Il-38 inhibits IL-36 signaling by binding to IL-1R6. IL-38 (aa 20-152) is released from apoptotic cells to limit inflammatory macrophage and downstream Th17 activation by blocking IL1RAPL1 (Interleukin-1 receptor accessory protein-like 1, TIGIRR-2) signaling. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus. - Monoclonal Antibody. Recognizes human and mouse IL-38. Isotype: Mouse IgG2bkappa. Clone: Nhat-1. Applications: ELISA, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 as a IL-1 family receptor antagonist. Il-38 inhibits IL-36 signaling by binding to IL-1R6. IL-38 (aa 20-152) is released from apoptotic cells to limit inflammatory macrophage and downstream Th17 activation by blocking IL1RAPL1 (Interleukin-1 receptor accessory protein-like 1, TIGIRR-2) signaling. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.
- ReactivityHuman, Mouse
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203