Anti-IL-6 Antibody [1-6]

HUABIO

Anti-IL-6 Antibody [1-6]

7

ImmunoFluorescence, Western Blot

WB,IHC-P,IF-Cell

Research Use Only

Monoclonal

1-6

2 mg/ml

Unconjugated

Il6

interleukin 6

Il-6, interleukin-6, B-cell hybridoma growth factor, interleukin HP-1

Mouse

IgG2b

Interleukin-6

Interleukin-6, or IL-6, is a multifunctional protein, 212 amino acids in length, that plays critical roles in host defense, immune response and hematopoiesis. IL-6 is constitutively expressed by epidermal Langerhans cells and its expression is induced in stimulated keratinocytes. IL-6, IL-1beta and TNFalpha act as endogenous pyrogens, regulating the fever response to bacterial invasion. The IL-6 receptor is a trimeric complex composed of an IL-6-specific alpha chain and a homodimer of the gp130 glycoprotein common to the IL-6, IL-11, CNTF, OSM and LIF receptors. Stimulation with IL-6 leads to gp130 homodimerization and the activation of associated kinases JAK1 and JAK2. Once activated, JAK1 and JAK2 phosphorylate Stat3, causing its nuclear translocation and transcription of Stat3-responsive genes. IL-6 has also been shown to activate the Ras/MAP kinase pathway, which regulates NFIL6 transcription.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161