Anti-IL-6R [D7715A7]

Absolute Antibody

Anti-IL-6R [D7715A7]

7

This antibody binds to IL-6R-positive cells, and blocks IL-6 binding (Vink et al, 1990; Coulie et al, 1990). This antibody is able to inhibit the growth of IL6-dependent plasmacytoma T1033C2 in vitro (Coulie et al, 1990). Administration of this antibody to mice prior to challenge with T1033C2 resulted in a protection rate of 60% and prolonged survival in tumour-bearing mice (Vink et al, 1990). This antibody has been used in flow cytometry to assess IL-6Ra expression (Hoge et al, 2013). When added to dendritic cells subject to CD40 activation in vitro, this antibody neutralises IL-6 and ablates the effect of CD40 activation (Grohmann et al, 2001).

Flow Cytometry, Neutralisation/Blocking

blocking; FC; therapeutic

Research Use Only

Monoclonal

D7715A7

Il6ra

interleukin 6 receptor, alpha

CD126, IL-6R, IL-6R-alpha, IL-6RA, Il6r, interleukin-6 receptor subunit alpha, IL-6 receptor alpha chain, IL-6 receptor subunit alpha, IL-6R 1, IL-6R subunit alpha

Mouse

IgG2a

Interleukin-6 receptor subunit alpha

This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Mouse

Mouse

This antibody was raised by immunising Lewis rats with OKT4 cells.

-20°C,2°C to 8°C

12352203