Anti-IL1RL1/ST2 Mouse mAb

PTM BIO

Anti-IL1RL1/ST2 Mouse mAb

5

Western Blot

WB

Research Use Only

Monoclonal

JMMR-1963

Unconjugated

Mouse

IgG

Interleukin-1 receptor-like 1

Interleukin 1 receptor-like 1, also known as IL1RL1 and ST2, is a protein that is encoded by the IL1RL1 gene in human. ST2 is a member of the interleukin 1 receptor family. The ST2 protein has two isoforms and is directly implicated in the progression of cardiac disease: a soluble form (referred to as soluble ST2 or sST2) and a membrane-bound receptor form (referred to as the ST2 receptor or ST2L). When the myocardium is stretched, the ST2 gene is upregulated, increasing the concentration of circulating soluble ST2. The ligand for ST2 is the cytokine Interleukin-33(IL-33). Binding of IL-33 to the ST2 receptor, in response to cardiac disease or injury, such as an ischemic event, elicits a cardioprotective effect resulting in preserved cardiac function.

Stable for 12 months from date of receipt/reconstitution.

Human, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203