Anti-IL23 (p19) [G23-8]

Absolute Antibody

Anti-IL23 (p19) [G23-8]

9

This antibody binds p19 subunit of mouse interleukin-23 (IL-23). IL-23A associates with IL-12B to form IL-23 interleukin which is a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to a heterodimeric receptor complex com

This antibody can neutralize the bioactivity of IL-23 with no effect on IL-12 p70 bioactivity. This antibody can be used for the detection of mouse IL-23 p19 in an ELISA (PMID: 18802055). This antibody was used in assay to determine the effect of anti-IL23p19 antibody on increase in IL-17 production after neutralization of IL-4 in T cells cultured with IL-4 DCs or with non transduced DCs (PMID: 17195211). This antibody was reported to inhibit lactic acid-induced enhancement of IL-17 production by OT-II mouse splenocytes that had been stimulated with the TLR ligand peptidoglycan (PGN) and bacillus Calmette-Guerin cell wall skeleton (BCG-CWS) (PMID: 18490716).

Functional Assay, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

G23-8

Il23a

interleukin 23, alpha subunit p19

IL-; IL-23; IL-23 subunit alpha; IL-23-A; IL-23p19; interleukin-23 subunit alpha; interleukin-23 subunit p19; p1; p19

Mouse

IgG2a

Interleukin-23 subunit alpha

This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG2b format for improved compatibility with existing reagents assays and techniques.

Mouse

-20°C,2°C to 8°C

12352203