Anti-iNOS Mouse mAb

PTM BIO

Anti-iNOS Mouse mAb

5

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

WB, ICC/IF

Research Use Only

Monoclonal

13451

Unconjugated

Mouse

IgG

Nitric oxide synthase, inducible

iNOS is a Nitric Oxide Synthase (NOS) that catalyzes the formation of nitric oxide (NO) and citrulline from L-arginine, oxygen, and cofactors.Nitric oxide catalyzed by iNOS is involved in host defense against protozoa, bacteria, fungi and viruses. Unlike constitutively expressed eNOS and nNos, iNOS is not usually expressed in quiescent cells. iNOS is transcriptionally induced in response to bacterial endotoxins, such as LPS and proinflammatory cytokines, in macrophages and various other cell types. Transcription factors involved in iNOS transcription include NF-kappaB, AP-1 and STAT. Different signaling pathways either promote (Jak1/2, PKC, c-Raf, p38 MAP kinase and p44/42 MAP kinase) or inhibit (PI3 kinase) iNOS expression depending on stimulus and cell type.

Stable for 12 months from date of receipt/reconstitution.

Mouse

Mouse

Protein G purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203