Anti-Integrin alpha E Antibody [SN62-06]

HUABIO

Anti-Integrin alpha E Antibody [SN62-06]

7

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

IHC-P

Research Use Only

Monoclonal

SN62-06

1 mg/ml

Unconjugated

ITGAE

integrin subunit alpha E

CD103, HUMINAE, integrin alpha-E, HML-1 antigen, antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide, human mucosal lymphocyte antigen 1, alpha polypeptide, integrin alpha-IEL, integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide), mucosal lymphocyte 1 antigen

Rabbit

IgG

Integrin alpha-E

Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene. CD103 binds integrin beta 7 (beta7- ITGB7) to form the complete heterodimeric integrin molecule alphaEbeta7, which has no distinct name. The alphaEbeta7 complex is often referred to as CD103 though this strictly refers only to the alphaE chain. Note that the beta7 subunit can bind with other integrin alpha chains, such as alpha4 (CD49d). The chief ligand for alphaEbeta7 is E-cadherin, a cellular adhesion molecule (CAM) found on epithelial cells. It is probably important for T cell homing to the intestinal sites and thymocyte contacts with thymic reticuloepithelial cells. Tregs are important for decreasing the immune response and appear to play a crucial role in the prevention of autoimmune diseases. Tregs are defined as CD4+/CD25+/Foxp3+ cells. Some CD4+/FoxP3- cells also express CD103 and have been attributed regulatory activity.

Human

Human

-20°C,2°C to 8°C

41116161