Anti Interleukin-13 Receptor Subunit Alpha-1 (IL-13Ra) D1 Domain mAb (Clone SS4B)

Cosmo Bio USA

Anti Interleukin-13 Receptor Subunit Alpha-1 (IL-13Ra) D1 Domain mAb (Clone SS4B)

16

Research Use Only

The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by IL13RA1 and IL4R, respectively. These two genes encode the proteins IL-13Ralpha1 and IL-4Ralpha. These form a dimer with IL-13 binding to the IL-13Ralpha1 chain and IL-4Ralpha stabilises this interaction. This IL-13 receptor can also instigate IL-4 signalling. In both cases this occurs via activation of the Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway, resulting in phosphorylation of STAT6. Phosphorylated STAT6 dimerises and acts as a transcription factor activating many genes, such as eotaxin.

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