Anti-IPO4 Mouse mAb

PTM BIO

Anti-IPO4 Mouse mAb

5

Western Blot

WB

Research Use Only

Monoclonal

10616

Unconjugated

Mouse

IgG

Importin-4

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein G purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203