Anti-IRAKM Antibody [SN64-07]

HUABIO

Anti-IRAKM Antibody [SN64-07]

7

ImmunoPrecipitation, Western Blot

WB,IP

Research Use Only

Monoclonal

SN64-07

1 mg/ml

Unconjugated

IRAK3

interleukin 1 receptor associated kinase 3

ASRT5, IRAKM, interleukin-1 receptor-associated kinase 3, IL-1 receptor-associated kinase M, inactive IL-1 receptor-associated kinase 3

Rabbit

IgG

Interleukin-1 receptor-associated kinase 3

The interleukin-1 receptor (IL-1R) associated kinase (IRAK) family plays a crucial role in the protective response to pathogens introduced into the human body by inducing acute inflammation followed by additional adaptive immune responses. IRAKs are essential components of the Interleukin-1 receptor signaling pathway and some Toll-like receptor signaling pathways. Toll-like receptors (TLRs) detect microorganisms by recognizing specific pathogen-associated molecular patterns (PAMPs) and IL-1R family members respond the interleukin-1 (IL-1) family cytokines. These receptors initiate an intracellular signaling cascade through adaptor proteins, primarily, MyD88. This is followed by the activation of IRAKs. TLRs and IL-1R members have a highly conserved amino acid sequence in their cytoplasmic domain called the Toll/Interleukin-1 (TIR) domain. The elicitation of different TLRs/IL-1Rs results in similar signaling cascades due to their homologous TIR motif leading to the activation of mitogen-activated protein kinases (MAPKs) and the IkappaB kinase (IKK) complex, which initiates a nuclear factor-kappaB (NF-kappaB) and AP-1-dependent transcriptional response of pro-inflammatory genes. Understanding the key players and their roles in the TLR/IL-1R pathway is important because the presence of mutations causing the abnormal regulation of Toll/IL-1R signaling leading to a variety of acute inflammatory and autoimmune diseases.

Human

Human

-20°C,2°C to 8°C

41116161