Anti-IRF6 Antibody [SD202-6]

HUABIO

Anti-IRF6 Antibody [SD202-6]

7

Western Blot

WB,IF-Cell,IF-Tissue,IHC-P

Research Use Only

Monoclonal

SD202-6

1 mg/ml

Unconjugated

IRF6

interferon regulatory factor 6

LPS, OFC6, PIT, PPS, PPS1, VWS, VWS1, interferon regulatory factor 6

Rabbit

IgG

Interferon regulatory factor 6

Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-alpha and beta) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-alpha and interferon-beta genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3gamma p48 and IFN consensus sequence-binding protein (ICSBP).

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161