Anti-IRF8 Mouse mAb

PTM BIO

Anti-IRF8 Mouse mAb

5

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

WB, ICC/IF

Research Use Only

Monoclonal

JMMR-2709

Unconjugated

Mouse

IgG

Interferon regulatory factor 8

IRF-8 is a member of Interferon regulatory factors family, which is expressed predominately in hematopoietic cells and is further increased upon treatment with interferon. IRF-8 can function as a transcription repressor of ICS-containing promoters. Expression of IRF-8 can lead to the downregulation of the anti-apoptotic protein Bcl-2. Originally described as being induced by IFN-gamma, IRF-8 expression is also elevated by IRF-alfa as well as IL-12 in NK and T cells. IRF-8 deficient mice have enhanced susceptibility to various pathogens and impaired production of interferons, as well as deregulated hematopoiesis that resembles chronic myelogenous leukemia. IRF-8 also regulates bone metabolism by suppressing osteoclast formation.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203