Anti-IDH1 Antibody [A11-B4]

HUABIO

Anti-IDH1 Antibody [A11-B4]

7

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P

Research Use Only

Monoclonal

A11-B4

2 mg/ml

Unconjugated

IDH1

isocitrate dehydrogenase (NADP(+)) 1

HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD, isocitrate dehydrogenase [NADP] cytoplasmic, NADP(+)-specific ICDH, NADP-dependent isocitrate dehydrogenase, cytosolic, NADP-dependent isocitrate dehydrogenase, peroxisomal, epididymis luminal protein 216, epididymis secretory protein Li 26, epididymis secretory sperm binding protein, isocitrate dehydrogenase (NADP(+)) 1, cytosolic, isocitrate dehydrogenase 1 (NADP+), soluble, oxalosuccinate decarboxylase

Mouse

IgG1

Isocitrate dehydrogenase [NADP] cytoplasmic

Isocitrate dehydrogenase (IDH) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (alpha-ketoglutarate) and CO2. In humans, IDH exists in three isoforms: IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. They localize to the cytosol as well as the mitochondrion and peroxisome. Mutations in IDH1 are also implicated in cancer. Originally mutations in IDH1 were detected in an integrated genomic analysis of human glioblastoma multiforme. In addition to being mutated in diffuse gliomas, IDH1 has also been shown to harbor mutations in human acute myeloid leukemia (AML).

Human

Human

Zebrafish

-20°C,2°C to 8°C

41116161