Anti-ITPK1 Antibody [JE64-35]

HUABIO

Anti-ITPK1 Antibody [JE64-35]

2

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

JE64-35

1 mg/ml

Unconjugated

ITPK1

inositol-tetrakisphosphate 1-kinase

ITRPK1, inositol-tetrakisphosphate 1-kinase, inositol 1,3,4-trisphosphate 5/6-kinase, ins(1,3,4)P(3) 5/6-kinase

Rabbit

IgG

Inositol-tetrakisphosphate 1-kinase

This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis.

-20°C,2°C to 8°C

41116161