Anti-JAK2 Antibody [SY0245]
ET1607-35
ApplicationsImmunoFluorescence, Western Blot
Product group Antibodies
ReactivityHuman, Mouse
TargetJAK2
Overview
- SupplierHUABIO
- Product NameAnti-JAK2 Antibody [SY0245]
- Delivery Days Customer7
- ApplicationsImmunoFluorescence, Western Blot
- Applications SupplierWB,IF-Cell
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDSY0245
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID3717
- Target nameJAK2
- Target descriptionJanus kinase 2
- Target synonymsJTK10, tyrosine-protein kinase JAK2, JAK-2, Janus kinase 2 (a protein tyrosine kinase)
- HostRabbit
- IsotypeIgG
- Protein IDO60674
- Protein NameTyrosine-protein kinase JAK2
- Scientific DescriptionJAK2 (Janus kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.
- ReactivityHuman, Mouse
- Reactivity SupplierHuman,Mouse
- Reactivity Supplier NoteRat
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC41116161