Anti-JunD Antibody [SD0830]

HUABIO

Anti-JunD Antibody [SD0830]

7

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IP

Research Use Only

Monoclonal

SD0830

1 mg/ml

Unconjugated

JUND

JunD proto-oncogene, AP-1 transcription factor subunit

AP-1, transcription factor JunD, activator protein 1, jun D proto-oncogene, transcription factor AP-1 subunit JunD, transcription factor jun-D

Rabbit

IgG

Transcription factor JunD

Transcription factor JunD is a protein that in humans is encoded by the JUND gene. The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage results in the production of different isoforms. The dominant negative mutant variant of JunD, known as deltaJunD or Delta JunD, is a potent antagonist of the deltaFosB transcript, as well as other forms of AP-1-mediated transcriptional activity. In the nucleus accumbens, deltaJunD directly opposes many of the neurological changes that occur in addiction (i.e., those induced by deltaFosB). deltaFosB inhibitors (drugs that oppose its action) may be an effective treatment for addiction and addictive disorders. Being an unnatural genetic variant, deltaJunD has not been observed in humans. JunD has been shown to interact with ATF3, MEN1, DNA damage-inducible transcript 3 and BRCA1.

Human

Human

-20°C,2°C to 8°C

41116161